Advanced B Complex

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A study by Stracke et al (2011) investigated the role of vitamin B complexes on mood and psychological strain associated with chronic work stress. Sixty participants completed a 3-month, double-blind, randomized, placebo-controlled trial in which personality, work demands, mood, anxiety, and strain were assessed. After 3 months of supplementation with two forms of high-dose vitamin B complex, treatment groups reported significantly lower personal strain and a reduction in confusion and depressed/dejected mood.

Earlier reports showed that by lowering homocysteine levels with vitamin B complex, supplementation could slow the rate of brain tissue breakdown in patients with mild cognitive impairment. In a double-blind study by de Jager et al (2012), 133 participants were given a vitamin B complex containing folic acid vitamin, vitamin B12 and Vitamin B6, or placebo.

Homocysteine levels decreased by 30% in the B-complex group compared to the placebo group. The B-complex group also showed improvements in cognition and memory, and an overall decrease in global clinical dementia scores.

Benfotiamine is a very specific and unique form of vitamin B1. In a double-blind, randomized placebo-controlled study by Stracke et al (1996), a B-complex composed of benfotiamine with Vitamin B6 and vitamin B12 was used to treat 24 diabetic patients each with multiple diabetic neuropathies (nerve damage from chronic high blood sugar or abnormal blood sugar levels). After 12 weeks of treatment, subjects given the benfotiamine vitamin B complex showed significant improvements in nerve conduction velocity. Clinical trials such as this have shown that benfotiamine can improve nerve function by 30% and decrease nerve pain by 50% among diabetics.